Remdesivir CAS No.:1809249-37-3
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Product details
Chemical Structure : GS-5734
CAS No.: 1809249-37-3
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GS-5734 (GS 5734;GS5734;Remdesivir)
Catalog No.: URK-V1174Â Â Only Used For Lab.
GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays.
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Biological ActivityGS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays.
GS-5734 (Remdesivir) suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers.
GS-5734 (Remdesivir) is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.
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Physicochemical Properties
M.Wt |
601.597 |
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Formula |
C28H36N5O8P |
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CAS No. |
1809249-37-3 |
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Storage |
Solide Powder -20 °C 3years; 4°C 2years |
In Solvent -80°C 6 Months -20°C 1 Months |
Solubility |
10 mM in DMSO |
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Chemical Name |
2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[1,2-b]pyridazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate |
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References1. Warren TK, et al. Nature. 2016 Mar 17;531(7594):381-5.
2. Jacobs M, et al. Lancet. 2016 Jul 30;388(10043):498-503.
3. Siegel D, et al. J Med Chem. 2017 Mar 9;60(5):1648-1661.
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